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Uganda to Receive More Ebola Vaccine Doses for Clinical Study

According to Dr. Mosoka Fallah, the Acting Director of the Science and Innovation Directorate at the Africa Centers for Disease Control (Africa CDC), Uganda initially received 2,160 doses to kick-start the study. Further shipments are expected as researchers work to determine the vaccine’s ability to prevent transmission among high-risk individuals.
17 Feb 2025 13:54
Dr Winters Muttamba, one of the scientists on the study shows off movable vaccine fridges being used.

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Uganda is set to receive additional doses of a vaccine being studied to assess its effectiveness in preventing Ebola infection among close contacts of those infected with the Sudan strain of the virus. The randomized clinical study was launched on February 3, just three days after a new Ebola outbreak was declared in the country. 

According to Dr. Mosoka Fallah, the Acting Director of the Science and Innovation Directorate at the Africa Centers for Disease Control (Africa CDC), Uganda initially received 2,160 doses to kick-start the study. Further shipments are expected as researchers work to determine the vaccine’s ability to prevent transmission among high-risk individuals.

However, with the vaccine trial progressing, he says they are ferrying into the country an additional 10,000 doses donated by IAVI. 

//Cue in:” The already existing doses …   

Cue out: … thing quite accelerated”. //    

As of February 10, which is when the Health Ministry last updated about the Ebola situation, nine people had been confirmed positive for the disease and Dr. Bruce Kirenga, the Principal Investigator of the study says it’s contacts of these cases that they are relying on to conduct the study.

He told URN in an interview, that 265 contacts had been identified by Friday and majority of them have already been consented to participate in the research.

//Cue in:” We have managed …   

Cue out: … with the trial”. //

Experts explain that to be able to do this study, they have randomized participants into eight rings and vaccination has already kicked off in seven of them. It should be noted that this study initially launched in 2022 during the Ebola outbreak in Mubende but was botched shortly after it start when Uganda was declared Ebola free. 

Asked whether the newly launched study may suffer the same fate as the previous one considering that the risk of further transmission is being estimated as minimal by other scientists observing the outbreak, Kirenga who is also the Executive Director of the Makerere University Lung Institute said when this happens, they will have no choice but to stop and wait for another similar outbreak.

//Cue in:” The rate at …    

Cue out: … is a trial base”. //

Uganda has had Ebola seven outbreaks of the Sudan strain of Ebola however there is currently no licensed vaccine available to effectively combat a potential future outbreak of Ebola disease from the Sudan species of the virus. 

Licensed vaccines exist only for the disease caused by Ebola virus, formerly known as Zaïre ebolavirus. Studies to establish the efficacy of these vaccines used the same approach being used in the current study.

When it comes to treatments, the strain currently circulating in Uganda has no approved ones, approved treatments are only available for Ebola virus.

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